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Brand names: Rheumatrex, Trexall

Methotrexate (brand names Rheumatrex, Trexall), abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer and autoimmune diseases. It acts by inhibiting the metabolism of folic acid. Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.

Generic Rheumatrex 2.5mg

What are methotrexate tablets?

METHOTREXATE (Rheumatrex®) is a chemotherapy agent that is used to treat certain kinds of cancer and other diseases. Methotrexate tablets are commonly used to treat inflammatory conditions such as rheumatoid arthritis and psoriasis. Methotrexate affects cells that are rapidly growing such as cancer cells, cells of psoriasis, and cells in your mouth and stomach. Methotrexate is used in treating a number of cancers including leukemias, lymphoma, breast cancer, and others. Generic methotrexate tablets are available.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
If you are HIV-positive or have acquired immunodeficiency syndrome (AIDS)
If you frequently drink alcohol-containing beverages
bleeding or blood disorders
cold sores or previous chickenpox or shingles infection
an active infection
kidney disease, including a history of kidney stones
liver disease
lung disease
recent radiation therapy or sunburn
stomach or intestinal disease or obstruction
ulcerative colitis
an unusual or allergic reaction to methotrexate, other chemotherapy, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant

How should I take this medicine?

Take methotrexate tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Do not take your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional, even if the tablets make you feel unwell. Do not stop taking except on your prescriber's advice.

The dose of methotrexate and how often it will be given may be different depending upon your disease and other medicines you are taking. If you have questions about the proper dose of your medicine, ask your prescriber or other health care professional.

What if I miss a dose?

If you miss a dose, skip that dose unless you remember within an hour or two, or your prescriber or health care professional tells you otherwise. Do not take double or extra doses. If you vomit after taking a dose, call your prescriber or health care professional for advice.

What drug(s) may interact with methotrexate?

anti-inflammatory drugs (NSAIDs, such as ibuprofen)
antibiotics and other medicines for infections
aspirin and aspirin-like medicines including bismuth subsalicylate (e.g. Pepto-Bismol®)
medicines for diabetes
phenytoin or fosphenytoin

Tell your prescriber or health care professional about all other medicines that you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

What side effects may I notice from taking methotrexate tablets?

Side effects will vary depending on the condition for which you are being treated, the dose, and the length of time you are taking methotrexate. If you want more information on possible side effects, ask your prescriber or health care professional to discuss this with you.

Side effects that you should report to your prescriber or health care professional as soon as possible:
symptoms of infection - fever or chills, cough, sore throat, pain or difficulty passing urine
symptoms of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
symptoms of decreased red blood cells (anemia) - unusual weakness or tiredness, fainting spells, lightheadedness
difficulty breathing, a non-productive cough
mouth and throat ulcers
redness, blistering, peeling or loosening of the skin, including inside the mouth
skin rash, hives, or itching
changes in vision
yellow coloring of skin or eyes

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
hair loss
increased sensitivity to sun and ultraviolet light
loss of appetite

What should I watch for while taking methotrexate tablets?

Visit your prescriber or health care professional for checks on your progress. You will need to have regular blood checks. The side effects of methotrexate can continue after you finish your treatment; report side effects promptly. It may take several weeks before you see an improvement in your rheumatoid arthritis or psoriasis.

Avoid alcohol-containing beverages while taking methotrexate. Methotrexate therapy for rheumatoid arthritis and psoriasis may cause damage to your liver. Your prescriber or health care professional will closely monitor your liver function while you are taking methotrexate. You may need to have a liver sample (a biopsy) taken before you receive methotrexate and during your therapy for rheumatoid arthritis or psoriasis.

Methotrexate may make you feel generally unwell. This is because methotrexate affects good cells as well as the disease cells. Report any side effects as above, but continue your course of medicine even though you feel ill, unless your prescriber or health care professional tells you to stop.

Methotrexate may decrease your body's ability to fight infections. Call your prescriber or health care professional if you have a fever, chills, sore throat or other symptoms of a cold or flu. Do not treat these symptoms yourself. Try to avoid being around people who are sick.

Methotrexate may harm your unborn baby. You should contact your prescriber immediately if you believe or suspect you or your partner have become pregnant while you are taking methotrexate. Both men and women must use effective birth control continuously while taking methotrexate. It is recommended that you use 2 reliable forms of contraception together. Men should continue to use contraception for at least 3 months after stopping methotrexate therapy. Women should continue to use contraception until after their first normal menstrual cycle after stopping methotrexate therapy.

If you are going to have surgery or dental work, tell your surgeon, dentist, or health care professional that you are taking methotrexate.

Methotrexate may cause you to more sensitive to the sun. Also methotrexate may cause a previous sunburn or radiation therapy reaction to reappear. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths.

Where can I keep my medicine?

Keep out of the reach of children in a container that small children cannot open.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Throw away any unused medicine after the expiration date.

Frequently asked questions:

What is a generic medication?

Wikipedia gives the following definition: “Generic drug (pl. generic drugs, short: generics) is a drug which is produced and distributed without a brand name. A generic must contain the same active ingredients as the original formulation. In most cases, it is considered bioequivalent to the brand name counterpart with respect to pharmacokinetic and pharmacodynamic properties. By extension, therefore, generics are assumed to be identical in dose, strength, route of administration, safety, efficacy, and intended use. Mind that the pills you will receive from us differ in appearance from the brand name ones. The looks of medications as well as brand names are the intellectual property of the brand manufacturer. Thus to avoid any accusation of copyright infringement we have to change the shape and the color of the generic pills as well as use the name of the active ingredient (generic name) instead of the brand name for printing on pills. Please be aware that the generic pills differ in appearance from the brand name medications. Our pills are round shaped and blister packed (10 pills per each blister). The name of the active ingredient as well as the weight are specified on the pill itself.

Why are generic pills cheaper than the brand name ones?

The principal reason for the reduced price of generic medicines is that the creation of the generic drug runs up less cost and therefore a lower price can be offered and still maintain profitability.
Manufacturers of generic drugs are mainly able to avoid the following three costs that brand name pharmaceutical companies incur: (1) costs associated with the research and development of the drug; (2) costs associated obtaining regulatory approval (i.e. proving safety and efficacy of a drug); and (3) marketing costs.
First, Generic manufacturers do not incur the cost of drug discovery and instead reverse-engineer existing brand name drugs to allow them to manufacture bioequivalent versions.
Second, generic manufacturers do not bear the burden of proving the safety and efficacy of the drugs through clinical trials - rather, generic manufacturers must prove the generic drug’s bioequivalancy to the existing drug.
Third, these companies receive the large benefit of the marketing and advertising that goes into pushing the innovator drug. The brand name drug has to prove itself in the eyes of the consumer, generic ones do not. The drugs that generic manufacturers are selling have been on the market for usually a decade or more and do not need additional advertising. For the same reason, generic manufacturers also do not give away sample doses to promote their products. The significant research, development and marketing costs incurred by the large pharmaceutical companies in introducing a new drug to the market is often cited as the reason for the high cost of new agents - they wish to recover these costs before the patent expires. Generic manufacturers do not incur these costs, with bioequivalence testing and manufacturing costing relatively little, and are able to charge significantly less than the brand. Buy discount Methotrexate (Rheumatrex) online. Order cheap generic Rheumatrex (Methotrexate) . Purchase Methotrexate (Rheumatrex) - low cost and price, but high quality.

Do you require a prescription?

However we would strongly recommend you to consult your doctor before taking a medication. You may have some diseases contra-indicated for taking certain kinds of medicines and your doctor will advise you what you can or cannot take.

Do you guarantee the quality of pills?

High quality of the medications we offer is the subject of our primary concern. The logic is very simple: the better the quality of goods is, the more customers we have. Thus we are very attentive and selective in the choice of the supplier, the quality of goods is thoroughly tested and the documentation is closely checked.

How do you ship orders? Will I have to sign for the package?

If sent by the standard unregistered mail the order will come in a plain envelope without any reference to content. The envelope will be left in your mail box. There is no need to sign for it. If sent by a courier, the recipient needs to sign for the package. All orders are shipped in discreet packaging. There is no mention on the outside of the package as to what is contained inside. Furthermore, your name or any other personal information will never be given or sold to any other company. Your privacy is our utmost concern.

Will my order be delivered in one package or you will divide it in case the order is large?

If an order includes 90 pills (or more) or if there are different types of medications in one order we will have to send the pills separately. Thus the delivery will take longer than 3 weeks since the packages are sent with the interval of approximately 7 days one by one. This is done to secure the delivery.


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All the data from the “checkout page” is directly transferred to the secure server of the payment system.
Payments security is ensured by encrypting your personal information during its transfer from the customer to the bank for the processing. We use 128 bit Secure Sockets Layer (SSL) software to encrypt the information you input.






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